Reply to 'Episode "Wilson" discussion'
Nov. 27th, 2009 03:04 am![[personal profile]](https://www.dreamwidth.org/img/silk/identity/user.png){kind=small}
eucleiaReply to the Episode "Wilson" discussion at ![[livejournal.com profile]](https://www.dreamwidth.org/img/external/lj-community.gif)
house_wilson, which ran way over the LJ reply character-limit. Possible spoilers ahead.
1) Will Wilson's friend live through the episode? Will he die even with Wilson's donation surgery? If he dies, what do you think Wilson will do?
One of the questions I have been asking myself these past few days.
Scientifically, even with immunosuppressive medication, there is a chance of graft rejection which may be caused a myriad of different factors (even if Wilson is type O, the universal donor), and can also happen at any time (perhaps immediately or years down the line). There are three main ones, but I don't think it would be sensible to go diving into them when we aren't even sure such a thing would happen. Also, the liver is a very special and curious organ. (^^) Liver transplantation is unique in that the risk of chronic rejection decreases over time, although recipients need to take immunosuppressive medication for the rest of their lives.
I have decided it is not possible to tell the conclusion to part 1 with the current information, so I'm going to simply wait until I watch the episode and be pleasantly (or not so pleasantly) surprised. Doesn't mean we can't hypothesize like good little scientists while we're waiting though. :D
2) According to the description of the global promo, is the transplant really that risky or is House worrying too much because it's Wilson? Will we get some sick!Wilson?
[Please note:
- I am making several hypotheses here.
- Also, I am no doctor, but I did do Biology to Advanced Level and my father passed away due to liver cancer, so there has been a fair amount of reading done on the subject.
- Another thing. If it's NOT liver transplant, the whole of parts 2 and 3 of this reply are VOID. xD]
Since Wilson's friend looks jaundiced in the promo, and kidney failure can be supplanted by dialysis, I hypothesize it is liver donation. Living donor liver transplantation (LDLT) is considered to be even more technically demanding than cadaveric donor liver transplantation. LDLT over here in the UK is practically nonexistent, though doctors are campaigning for a change.
Mortality rate, whilst lowish considering modern day amenities (~0.5-1%), is still significantly higher than that of say, kidney donation (~0.03%). That being said, those were global averages, and considering by country gives an estimation of LDLT mortality being reported at 0% (Japan), 0.3% (USA) and <1% (Europe), with risks likely to improve further as surgeons gain more experience in this procedure. Postoperative donor complications in Japan were reported to be 12% in one study. Lancet. 2003 Aug 30;362(9385):674-5. Very occasionally, a second operation is needed.
While the heart drives the body and the brain is the conductor for the whole orchestra that is the human body, the liver is basically the powerhouse for the entire system. Most of the body's major chemical reactions take place in the liver, and the surplus heat generated by such reactions are used to heat your body via both radiative (rest your hand over your abdomen; you'll find the skin there intrinsically hotter than that over anywhere else on the surface of your body) and circulatory means.
Several MAJOR arteries run through and around the liver - most notably the almighty hepatic portal vein (which provides ~75% of the liver's blood supply), and the hepatic arteries. Nick one of those accidentally and there's going to be problems.
3) Are there renewed hopes of seeing House "nurse Wilson back to health" with these spoilers? Will House have to help Wilson once again? Do we dare hope for some hugging or hand holding?
The liver is the only internal human organ capable of natural regeneration of lost tissue; as little as 25% of a liver can regenerate into a whole liver (which, might I add in a personal opinion, is PRETTY FUCKING EPIC 8DD). A human liver is known to grow back in no less than 8 years. However recent studies seem to suggest regeneration may occur faster than originally thought:
"Expressed as a percentage of the original volume, the mean liver volume 6 months after hepatectomy was 90.70% ± 12.47% in this series. For right graft donors, mean liver volume after 6 months was 89.68% ± 12.37% of the original liver volume, whereas that for left graft donors was 91.99% ± 12.6%. Only 26 of the 109 (23.85%) donors were able to achieve full regeneration 6 months post-donation." Liver Regeneration and Splenic Enlargement in Donors after Living-Donor Liver Transplantation (You can download the full pdf on the page if you are interested.)
More recently, adult-to-adult liver transplantation has been done using the donor's right hepatic lobe which amounts to 60% of the liver. Due to the ability of the liver to regenerate, both the donor and recipient end up with normal liver function if all goes well. This procedure is more controversial as it entails performing a much larger operation on the donor, and indeed there have been at least 2 donor deaths out of the first several hundred cases. A recent publication has addressed the problem of donor mortality, and at least 14 cases have been found. (Howard J. Worman. The Liver Disorders Sourcebook, McGraw-Hill, 1999) The risk of postoperative complications (and death) is far greater in right sided hepatectomy than left sided operations.
In conclusion, hopefully this recovery time will provide ample opportunity to show some affection/feelings. ;) I know I'm game to see some!
4) Will there be repercussions to this episode that will continue on in episode 11 (which apparently will have lots of House/Wilson)?
Probably. Both mental and physical, I can only assume (the latter of which I addressed above).
5) Happy that there will be a bit of Huddy storyline on this episode Y / N?
N = No, not "happy". But only because in my highly biased opinion, I think that "Huddy" storyline has no place in such an episode. And also because I sullenly predict that there will be little House/Wilson in the "Cuddy-centric" episode.
6) Will this be one of the best episodes of the season or of THE WHOLE WORLD Y / Y? =D
Gosh, I certainly hope so. :D :D :D
house_wilson, which ran way over the LJ reply character-limit. Possible spoilers ahead.1) Will Wilson's friend live through the episode? Will he die even with Wilson's donation surgery? If he dies, what do you think Wilson will do?
One of the questions I have been asking myself these past few days.
Scientifically, even with immunosuppressive medication, there is a chance of graft rejection which may be caused a myriad of different factors (even if Wilson is type O, the universal donor), and can also happen at any time (perhaps immediately or years down the line). There are three main ones, but I don't think it would be sensible to go diving into them when we aren't even sure such a thing would happen. Also, the liver is a very special and curious organ. (^^) Liver transplantation is unique in that the risk of chronic rejection decreases over time, although recipients need to take immunosuppressive medication for the rest of their lives.
I have decided it is not possible to tell the conclusion to part 1 with the current information, so I'm going to simply wait until I watch the episode and be pleasantly (or not so pleasantly) surprised. Doesn't mean we can't hypothesize like good little scientists while we're waiting though. :D
2) According to the description of the global promo, is the transplant really that risky or is House worrying too much because it's Wilson? Will we get some sick!Wilson?
[Please note:
- I am making several hypotheses here.
- Also, I am no doctor, but I did do Biology to Advanced Level and my father passed away due to liver cancer, so there has been a fair amount of reading done on the subject.
- Another thing. If it's NOT liver transplant, the whole of parts 2 and 3 of this reply are VOID. xD]
Since Wilson's friend looks jaundiced in the promo, and kidney failure can be supplanted by dialysis, I hypothesize it is liver donation. Living donor liver transplantation (LDLT) is considered to be even more technically demanding than cadaveric donor liver transplantation. LDLT over here in the UK is practically nonexistent, though doctors are campaigning for a change.
Mortality rate, whilst lowish considering modern day amenities (~0.5-1%), is still significantly higher than that of say, kidney donation (~0.03%). That being said, those were global averages, and considering by country gives an estimation of LDLT mortality being reported at 0% (Japan), 0.3% (USA) and <1% (Europe), with risks likely to improve further as surgeons gain more experience in this procedure. Postoperative donor complications in Japan were reported to be 12% in one study. Lancet. 2003 Aug 30;362(9385):674-5. Very occasionally, a second operation is needed.
While the heart drives the body and the brain is the conductor for the whole orchestra that is the human body, the liver is basically the powerhouse for the entire system. Most of the body's major chemical reactions take place in the liver, and the surplus heat generated by such reactions are used to heat your body via both radiative (rest your hand over your abdomen; you'll find the skin there intrinsically hotter than that over anywhere else on the surface of your body) and circulatory means.
Several MAJOR arteries run through and around the liver - most notably the almighty hepatic portal vein (which provides ~75% of the liver's blood supply), and the hepatic arteries. Nick one of those accidentally and there's going to be problems.
3) Are there renewed hopes of seeing House "nurse Wilson back to health" with these spoilers? Will House have to help Wilson once again? Do we dare hope for some hugging or hand holding?
The liver is the only internal human organ capable of natural regeneration of lost tissue; as little as 25% of a liver can regenerate into a whole liver (which, might I add in a personal opinion, is PRETTY FUCKING EPIC 8DD). A human liver is known to grow back in no less than 8 years. However recent studies seem to suggest regeneration may occur faster than originally thought:
"Expressed as a percentage of the original volume, the mean liver volume 6 months after hepatectomy was 90.70% ± 12.47% in this series. For right graft donors, mean liver volume after 6 months was 89.68% ± 12.37% of the original liver volume, whereas that for left graft donors was 91.99% ± 12.6%. Only 26 of the 109 (23.85%) donors were able to achieve full regeneration 6 months post-donation." Liver Regeneration and Splenic Enlargement in Donors after Living-Donor Liver Transplantation (You can download the full pdf on the page if you are interested.)
More recently, adult-to-adult liver transplantation has been done using the donor's right hepatic lobe which amounts to 60% of the liver. Due to the ability of the liver to regenerate, both the donor and recipient end up with normal liver function if all goes well. This procedure is more controversial as it entails performing a much larger operation on the donor, and indeed there have been at least 2 donor deaths out of the first several hundred cases. A recent publication has addressed the problem of donor mortality, and at least 14 cases have been found. (Howard J. Worman. The Liver Disorders Sourcebook, McGraw-Hill, 1999) The risk of postoperative complications (and death) is far greater in right sided hepatectomy than left sided operations.
In conclusion, hopefully this recovery time will provide ample opportunity to show some affection/feelings. ;) I know I'm game to see some!
4) Will there be repercussions to this episode that will continue on in episode 11 (which apparently will have lots of House/Wilson)?
Probably. Both mental and physical, I can only assume (the latter of which I addressed above).
5) Happy that there will be a bit of Huddy storyline on this episode Y / N?
N = No, not "happy". But only because in my highly biased opinion, I think that "Huddy" storyline has no place in such an episode. And also because I sullenly predict that there will be little House/Wilson in the "Cuddy-centric" episode.
6) Will this be one of the best episodes of the season or of THE WHOLE WORLD Y / Y? =D
Gosh, I certainly hope so. :D :D :D
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no subject
Date: 2009-11-29 01:07 am (UTC)The first (American) promo was when first noticed jaundice, I believe. In the scene right after Wilson says, and I quote, "You've only got about 24 hours left." Tucker looks incredibly yellow, so I assumed jaundice and thus liver failure.
My personal opinion is that House probably thinks he loves Cuddy, or that he "wants" to love her, because that is what he thinks he should do/be feeling. I hover back to season 5's finale, Both Sides Now, where House's own mind in the form of Amber chastises him with the words, "So this is the story you made up about yourself. It's a good one," before his mind conjures Kutner with the rather final words of, "Too bad it isn't true."
I'm also drawing on last week's Ignorance is Bliss. The POTW storyline where he was deliberately dumbing himself down since it was the only way from his point of view that he could sustain happiness, and because he wanted to want his wife. Frankly, on a very personal note, I was horrified that House approved of the patient continuing to destroy his intellect. It may be lonely at the top, but House has had Wilson beside him for near two decades. Seems like he's still taking Wilson for granted, but I have high hopes this will finally change after 6x10, if Wilson's very life is at risk.
I hope for all the House/Wilson touching possible. :D
I find it interesting that whilst I cringe in revulsion/embarrasment by proxy and bemoan in "not again"-ness at any House/Cuddy touching, and have thus come to fear it, I have negligible to no such fears of House/Wilson touching. While I admit I may be biased towards the "slash" so to speak, my feelings are that any touching on the part of House/Wilson would not be born out of lust, and may thus be why I am not adversed to anything physical hapening between them.
Reply continued below due to LJ-character limit.
no subject
Date: 2009-11-29 01:08 am (UTC)Please be aware that I am not judging you, or anyone else that may read this for that matter (I am also well aware this next statement of mine may seem contradictory to that, but it is meant to illustrate a different point rather than contempt), but I have a massive disdain for people who cannot control their own behaviour with their mind. I think that's why I scoff at people who can't control either their (depending on what mood I'm and and what the circumstances are surrounding the feelings) lust/love - my brain wants to believe that one can overcome hormone-based lust based on willpower. It is also why I scoff (not intentionally - I am trying to rectify this horrid behaviour) at those who gravitate towards one another on pure lust and no apparent logic, the latter of which I have become convinced does not exist at all with House/Cuddy (I refuse to even mention the contraction "Huddy" - sounds awful).
I see why the writers gave Cuddy the storyline of wanting a child of her own, but being unable to conceive because of her age, as it is a real and serious and growing problem for many women around the world whom originally passed on the opportunity of family to further careers (something which I actually admired Cuddy for during the first couple of seasons). Wanting a child of her own does not make her any less of a "strong" woman. However, I am personally convinced that we are have long since past that, and are now somehow into the idea that the traditional nuclear family is the only way for Cuddy to be happy, and the only way for House to be happy/fufilled while we're at it. Having a father in the family does not make a family functional, but Cuddy no longer seems satisfied with just a child; she wants the man she fancies (I refer to the UK term here, where "fancy" means "to have a crush on") as well, nevermind incompatible personalities and objectifying comments (which I am convinced she unconscously likes), and my respect for her has dwindled (along with her clothing) since mid-season 3 or so.
As for Tivo, I assume that is the American version of Sky+? We used to have Sky (not Sky+, the latter which allows you to record your favourite programmes), but they started to jack the price up by a good amount each year, and considering we had hundreds of channels which we did not watch, we ended up cancelling the package. Anyways, I have to watch House on the internet until the DVDs come out, so there's unfortunately no fast-forwarding. Even if there was, however, my morbid curiosity would eventually win out, and it would likely be a case of
"Huddy"curiosity kill thePhoenixcat.And I completely agree that the characters of House and Wilson have remarkable chemistry. <3 They should so get together, fly off to Canada and marry already.
no subject
Date: 2009-11-29 03:13 am (UTC)I hope for all the House/Wilson touching possible. :D
I find it interesting that whilst I cringe in revulsion/embarrasment by proxy and bemoan in "not again"-ness at any House/Cuddy touching, and have thus come to fear it, I have negligible to no such fears of House/Wilson touching. While I admit I may be biased towards the "slash" so to speak, my feelings are that any touching on the part of House/Wilson would not be born out of lust, and may thus be why I am not adversed to anything physical hapening between them.
I think the touching will be borne of love, affection, knowledge of what each needs emotionally and physically, and comfort. I too find the Huddy touching cringeworthy and just plain gross. Technically, the actors, directors are doing a good job but the Huddy physical scenes seem to lack something. I think it has to so with chemistry between the two actors - really it's just not there. Everyone knows that HL and RSL are very close friends and they enjoy working together. I think someone posted some candid shots of Epic Fail and there;s one where HL is chewing on a carrot and smiling at RSL. Of RSL looks like he's somewhere else. Now back to the characters.
I don't see House moving on Wilson in a sexual way. I really think it will be about drawing Wilson out, providing some physical comfort, and House showing Wilson how he really feels about him. It may be sexy, romatic and HOT, but I don't think sex will be the motive behind any H/W touching. I definitely think we'll see them in bed TOGETHER. We start out with them sharing a hotel room, Then House drugs and depants Wilson. Later, recall that Wilson accused House of not asking him what he wants or respecting his wishes. I think in any physical scene, we're going to see House doing both. Maybe Wilson ask House to sleep with him or House ask Wilson if he can join him. Whichever way it happens, it wil be about love and respect and comfort - NOT SEX AND LUST (which rarely if ever translate well onscreen)